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Member Profile

J. Michael Wyss



  • Higher Ed: Science, Higher Ed: Administrator, Researcher 


Michael Wyss is Director of the UAB Center for Community Outreach Development (CORD), and thereby directs much of the University's K-12 STEM education outreach, and he developed several new programs and expanded previously successful programs. Further, Dr. Wyss has formed outstanding alliances with all of the area school districts. Dr. Wyss has focused CORD on empowering K-12 science, math and technology education, especially for underrepresented and minority students, in large part, by providing their teachers the requisite knowledge base and effective, inquiry-based tools to educate their students. Dr. Wyss's biomedical research focuses on two major areas. The first research focus is on neuronal plasticity and grows out of his studies demonstrating that a specific group of pyramidal neurons in the rat retrosplenial cortex displays a dramatic alteration in their structure as the animal ages. Concurrent with these changes in structure, they have demonstrated that cellular, molecular and behavioral changes occur, including a significant decrease in spatially learning. The second research focus is on the mechanisms by which the hypothalamus regulates blood pressure in salt-sensitive individuals. This work has recently focused on the ability of polyphenols to blunt hypertension. These studies employ cellular and molecular techniques, transgenic manipulations in mouse, neural recordings, nerve pathway tracing and plasticity measures, biochemical analyses, MS/MS, FRAP/FRET, etc. This work is currently most focused on the ability of puerarin to blunt metabolic disease components, especially the ability of this polyphenol to regulate lipid metabolism and insulin sensitivity. 



Rajbhandari R, N. Peng, R. Moore, A. Arabshahi, J.M. Wyss, S. Barnes, J.K. Prasain. Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometry. J Agric Food Chem.59:6682-6688, 2011. PMID:21634376

Jian S, Sripanidkulchai K, Wyss JM, Sripanidkulchaia B. Curcuma comosa improves learning and memory function on ovariectomized rats in a long-term Morris water maze test. J Ethnopharm, 6:70-75, 2011.

Carlson, S.H. and J.M. Wyss. Mechanisms Underlying Hypertension and Obesity. Hypertension, 57:375-378, 2011. PMID:21263117

Su , J., K. Sripanidkulchai , Y. Hu , J.M. Wyss , B. Sripanidkulchai. The effect of ovariectomy on learning and memory and relationship to changes in brain volume and neuronal density. International Journal of Neuroscience, 122:549-59, 2012. PMID:22578066.

Jirakulsomchok, D, S. Napawachirahat, N. Kunbootsri, T. Suttitum, P. Wannanon, J. M. Wyss and S. Roysommuti. Impaired renal response to portal infusion of hypertonic saline in adriamycin-treated rats. Clinical and Expeimental Pharmacology and Physiology, 39:636-41, 2012. PMID:22564274

Prasain, J.K., N. Peng, R. Rajbhandari, J. M. Wyss. The Chinese Pueraria root extract (Pueraria lobota) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomedicine, 20:17- 23, 2012. PMID:23123226.

Roysommuti, S. and Wyss, J.M. Perinatal taurine exposure on infants. Clinical Medicine, In Press, 2012.

Jirakulsomchoka D, N. Soikhama, N. Kunbootsria, P. Wannanonda, T. Suttituma, T. Tongoona, S. Roysommuti and J.M. Wyss. Impaired renal response to portal infusion of hypertonic saline in adriamycin-treated rats. Pharmacol and Physiology, in Press, 2012.

Roysommuti, S and J. M. Wyss. Taurine exposure effects on arterial pressure control. Bioactive Foods in Chronic Disease States, in Press, 2012.

Vitturi, D.A., C. Sun, V. Harper, B. Thrash-Williams, N. Cantu-Medellin, B. Chacko, N. Peng, Y. Dai, J. M. Wyss, T. Townes, R.P. Patel. Antioxidant functions for the hemoglobin beta 93 cysteine residue in erythrocytes and in the vascular compartment in vivo. Free Radical Biology and Medicine, In Press, 2012.

Roysommuti, S. and J.M. Wyss. Perinatal taurine exposure affects arterial pressure control. Amino Acids, In Press, 2012.